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Artificial Intelligence Molecular Screen (AIMS) Awards

In-Kind Support to USA, Canada, and International Scientists
at Nonprofit Institutions and IHEs to Discover New Medications

Agency Type:

Foundation / Corporation

Funding Source:

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Atomwise

Deadline Date:

12/09/19

Description:

Request a Grant Writer

In-kind support to USA, Canada, and International scientists at nonprofit research institutions and IHEs to discover new life-saving medication. Services are intended to support proposals involving protein targets that are implicated in human disease.

The goal of this program is to broaden the pool of scientists pursuing drug discovery. To advance this goal, Atomwise will award researchers with a customized virtual screen using cutting-edge Artificial Intelligence (AI) technology, free chemical compounds for physical screening, and technical support from medicinal chemists and computational biologists.

Atomwise will consider any project that could benefit from Atomwise's expertise and technology. Project topics may be in any area, including those in animal health, biotechnology, human biology, medicine, microbiology, plant biology, and virology.

Ideally, applicants will have both of the following:

  1.  A target protein with:
    • An X-ray crystal, Cryo-EM, or NMR structure, or with close sequence homology to protein with available structures.
    • An identified site for the chemical compounds to bind.
  2. An established assay(s) that can:
    • Test at least 72 small molecules, AND
    • Directly measure protein function or activity, AND
    • Measure IC50 or equivalent.

GrantWatch ID#:

GrantWatch ID#: 187047

Estimated Size of Grant:

AIMS Awards provide researchers with the following at no cost:
- Customized virtual screen of chemical compounds using AtomNet™;
- Approximately 72 Small molecule compounds predicted to bind to their selected protein;
- Compounds that can serve as controls, if available;
- Ordering of compounds from suppliers, resuspension and dilution to a convenient concentration and aliquoted onto microtiter plates, QC verification by mass spectrometry, and delivery to the researcher’s lab;
- Randomized “blinding” of compounds;
- Support from Atomwise medicinal chemists and computational biologists; and
- Additional chemical compounds and support if criteria are met.

Additional Eligibility Criteria:

Applicants must be a Principal Investigator. Research scientists, graduate students, or postdoctoral researchers can apply for the AIMS Award on behalf of or with the approval and support of a Principal Investigator; in these cases, the applicant with responsibility for the performance of the project must still be the Principal Investigator. The research must be performed at a non-profit university or research institute.

Pre-Application Information:

Timeline:
- Extended Deadline: December 9, 2019
- Announcement of recipients: January 2020

AIMS is a streamlined program. Short applications are submitted online, and recipients will be announced about three months from the submission deadline. No preliminary data is required.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply online:
https://atomwise.wpengine.com/

For questions, please contact:
Nick DeHaan
academics@atomwise.com

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta   British Columbia   Manitoba   New Brunswick   Newfoundland and Labrador   Northwest Territories   Nova Scotia   Nunavut   Ontario   Prince Edward Island   Quebec   Saskatchewan   Yukon

Israel

International country outside of the USA, Israel and Canada.